基本情况：

于晓兵 ，男 ，博士学位 ，主任医师，澳门新葡官网进入骨八科主任，大连市青年才俊。

简历介绍：

学科情况：澳门新葡官网进入骨八科（脊柱二科）成立于2016年3月，现有医护人员13人，床位32张，骨八科（脊柱二科）是一个年轻、团结向上并富有朝气的团队，在科主任于晓兵带领下，组建了合理的人才梯队，技术力量雄厚，能开展各类复杂的脊柱外伤、退变、肿瘤及侧弯、后凸畸形的治疗。目前科室以全脊柱系统治疗为发展方向，同时以微创的方法治疗脊柱骨折的治疗为支撑点，以腰椎间盘突出症、脊柱骨折等治疗为突破点，在脊柱疾病的诊治方面均有很高的造诣，尤其擅长胸腰椎骨折微创手术。在胸腰椎椎体骨折微创治疗上有独到的见解和独特方法。

研究方向:脊柱相关疾病研究

主持承担项目情况:

1.大连市科技计划项目（在研），2021JJ13SN68，大鼠骨髓间充质干细胞来源的外泌体加载siRNA治疗脊髓损伤的机制研究，10万，主持，负责课题设计及论文撰写。

2.国家自然科学基金面上项目（已结题）,81371942,髓芯减压联合骨髓基质干细胞移植治疗不同类型血液循环障碍导致的犬早期股骨头坏死的实验研究,2014/1-2017/12,70万,主要参加人员，负责标本检测及论文撰写。

3.国家自然科学基金面上项目（已结题）,81201398,压控下 BMMSCs/PRF 双层复合体 治疗塌陷后股骨头坏死软骨损伤的机制研究,2013/1-2015/12,23 万，主要参加人员，负责标本检测及论文撰写。

4.大连市卫生局课题（已结题）,数字减影血管造影术指导下股骨头坏死微创治疗的实验研究,2014/1-2014/12,2 万,主持，负责标本检测及论文撰写。

5.辽宁省自然基金（已结题）:(2015020669)在激素性兔股骨头坏死中 Akt/IGF-1激活Wnt/β-catenin信号通路活性的机制究,2015/10-2017/12,20万,主持，负责课题设计及论文撰写。

6.大连市卫生局课题（已结题），不同应力对大鼠股骨头坏死自身修复过程中胰岛素 样生长因子-1 表达的影响,2015/1-2016/12,2万，主持，负责课题设计及论文撰写。

7.大连大学博士启动基金（已结题），不同应力对大鼠股骨头坏死自身修复过程中胰 岛素样生长因子-1表达的影响，2015/1-2016/12，1万，主持，负责课题设计及论文撰写。

8.博士后课题（已结题），Mg/PLLA 生物可吸收接骨板的制备及生物学性能研究，2015/12-2017/12，21万，主持，负责课题设计及论文撰写。

社会兼职及荣誉：

中国医师协会骨科医师分会第五届委员会脊柱创伤学组委员

中国医师协会显微外科分会神经脊柱专委会委员

代表性研究成果：

代表性文章：

1.Huang W, Lin M, Yang C, Wang F, Zhang M, Gao J, Yu X. Rat Bone Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-494 Promoting Neurofilament Regeneration and Behavioral Function Recovery after Spinal Cord Injury. Oxid Med Cell Longev. 2021 Oct 1;2021:1634917. doi: 10.1155/2021/1634917. PMID: 34635862; PMCID: PMC8501401.

2.Lin M, Qu M, Huang W, Liu T, Duan R, Yuan Y, et al. Clinical effectiveness of percutaneous vertebroplasty in conjunction with postoperative radiotherapy in the treatment of spinal metastases[J]. Journal of Cancer Research and Clinical Oncology, 2021, 147(3): 835-844.

3.Huang W, Qu M, Li L, Liu T, Lin M, Yu X. SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats[J]. Stem Cell Res Ther, 2021, 12(1): 334.

4.Duan R, Qu M, Yuan Y, Lin M, Liu T, Huang W, et al. Clinical Benefit of Rehabilitation Training in Spinal Cord Injury: A Systematic Review and Meta-Analysis[J]. Spine (Phila Pa 1976), 2021, 46(6): E398-E410.

5.Wang T N, Wu B L, Duan R M, Yuan Y S, Qu M J, Zhang S, et al. Treatment of Thoracolumbar Fractures Through Different Short Segment Pedicle Screw Fixation Techniques: A Finite Element Analysis[J]. Orthop Surg, 2020, 12(2): 601-608.

6.Huang W, Liu T, Duan R, Yuan Y, Qu M, Zhang M, et al. Primary multiple angiosarcoma of vertebra: A case report[J]. Medicine (Baltimore), 2020, 99(50): e23587.

7.Yuan Y, Yu X. Therapeutic effects of rehabilitation training methods on spinal cord injury: a meta-analysis[J]. The Lancet, 2019, 394: S27-.

8.Yuan Y, Duan R, Wu B, Huang W, Zhang X, Qu M, et al. Gene expression profiles and bioinformatics analysis of insulin-like growth factor-1 promotion of osteogenic differentiation[J]. Mol Genet Genomic Med, 2019, 7(10): e00921.

9.Yu X, Zhang S, Zhao D, Zhang X, Xia C, Wang T, et al. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494[J]. Int J Mol Med, 2019, 43(4): 1758-1768.

10.Yu X, Liu T, Zhao D, Yang K, Zhang X, Zhang M, et al. Efficacy and Safety of Pregabalin in Neuropathic Pain Followed Spinal Cord Injury: A Review and Meta-Analysis of Randomized Controlled Trials[J]. Clin J Pain, 2019, 35(3): 272-278.

11.Yu X, Huang W, Zhao D, Yang K, Tan L, Zhang X, et al. Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study[J]. Colloids Surf B Biointerfaces, 2019, 174: 280-290.

12.Xiaobing Yu,MD*Tienan Wang,MD Baolin Wu,MD Dewei Zhao,MD Ke Yang,MD Xiuzhi Zhang,MD Meng Zhang,MD Shuo Zhang,MD Wei Huang,MD Tao Liu,MD Weiting Yu,MD Junlei Li,MD Identification of gene co-expression modules, hub genes and pathways related to spinal cord injury using integrated bioinformatics methods.JOURNAL OF CELLULAR BIOCHEMISTRY .IF:2.95 (accepted in 2018)

13.Xiaobing Yu,MD Wei Huang,MD Lili Tan ,MD Xiuzhi Zhang,MD Junlei Li,MD Meng Zhang,MD Shuo Zhang,MD Tao Liu,MD Baolin Wu,MD Dewei Zhao,MD* Ke Yang,MD*.Study of engineered low-modulus Mg/PLLA composites as potential feasible orthopaedic implants: An in vitro and in vivo study.Colloids and Surfaces B: Biointerfaces.IF:3.99(2018)

14.Yu Xiaobing*,Zhang Shuo, Zhao Dewei, Zhang Xiuzhi, Xia Chongjun, Wang Tienan,Zhang Meng, Liu Tao, Huang Wei, Wu Baolin. SIRT1 inhibits apoptosis of spinal cord injury in vivo and vitro model through microRNA-494.International journal of molecular medicine.IF:2.78(accepted in 2018)

15.Xiaobing Yu,MD*，Tao Liu,MD，Dewei Zhao,MD，Ke Yang,MD，Xiuzhi Zhang,MD， Meng Zhang,MD，Shuo Zhang,MD，Wei Huang,MD，Baolin Wu,MD，Junlei Li,MD

.Efficacy and safety of pregabalin in neuropathic pain followed spinal cord injury: a review and meta-analysis of randomized controlled trials.The Clinical Journal of Pain.IF=3.209(2018)

16.Xiaobing Yu, MD*Wei Huang MD , Shuo Zhang MD , Tao Liu MD, Baolin Wu MD , Ruimeng Duan MD ,Yashuai Yuan MD ,Mingjia Qu MD ,Xiuzhi Zhang MD,Meng Zhang MD ,Depeng Shang MD .Mesenchymal Stem Cells-Derived Exosomes loaded with siRNA for Spinal Cord Injury Treatment in rat.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65(2018)

17. Xiaobing Yu MD ,Yashuai Yuan MD , Ruimeng Duan MD , Mingjia Qu MD ,Shuo Zhang MM , WeiHuang MD ,Tao Liu MD ,Baolin Wu MD ,Meng Zhang MD , Depeng Shang MD , Dewei Zhao MD*.An experimental study of the effects of different stress stimuli on the expression of insulin-like growth factor -1 in the repair of femoral head necrosis.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65(2018)

18. Xiaobing Yu, MD* Shuo Zhang,Dewei Zhao MD,Xiuzhi Zhang MD,Jianchuan Wang,Chongjun Xia,Tienan Wang.The Role of Original Hematoma in Accelerating the Fracture Healing for the Treatment of Intertrochanteric Fracture.Journal Basic & Clinical Pharmacology & Toxicology.IF:2.65( 2018)

19.Yu XB, Zhao DW*, Zhong SZ, Liu BY, Wang BJ, Liu YP, Zhang Y, Cui DP, Fu DP, Xie H. Prospective and comparative analysis of internal fixation of femoral neck fractures with or without vascularized iliac graft in young adults. Orthopedics. 2013 Feb 1;36(2):e132-8. doi: 10.3928/01477447-20130122-12.

20.Yu X, Zhao D, Huang S, Wang B, Zhang X, Wang W, Wei X. Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults. BMC Musculoskelet Disord. 2015 Nov 2;16(1):329.

专利及成果转化情况：

1.一种关节镜手术半月板缝合器

2.一种生物材料拼接的脊柱椎间融合器

3.一种胶原基可降解脊柱融合器及其制备方案

出版论著:

1.《股骨头缺血性坏死的微创治疗技术》人民卫生出版社

2.《儿童股骨头缺血性坏死的诊断与治疗》，人民卫生出版社

3.《骨科进修医师指导手册》，辽宁科技出版社

4.《股骨头缺血性坏死的修复与再造》（第2版），人民卫生出版社

5.《现代骨科学》，科学技术文献出版社

获奖情况:

教育部科技进步一等奖1项，辽宁省科技进步奖一等奖1项,大连市科学技术奖二等奖1项，获2015年大连市青年科技奖，获2015年中国医师协会骨科分会授予的优秀青年医师奖。

招聘博士后的专业方向要求：

生物医药类：脊柱相关疾病研究

医学相关类：力学、材料科学与工程等

工作照照片：