基本情况：

朴丰源，男，博士，教授，博导，现为本院特聘专家。

简历介绍：

1983年毕业于中国医科大学本科，1990年获中国医科大学卫生毒理学硕士学位。1991年留学日本国立三重大学医学部公众卫生学教研室，1996年获医学博士学位，并在该教研室任助教、讲师，2004年破格晋升为副教授。在日本工作期间，曾主持承担或分担日本文部科学省、环境省、三重县及大学的多项研究课题，获得五千多万日元科研经费。2005年作为海外高层次人才引进聘为大连医科大学教授，博士生导师。曾担任劳动卫生与环境卫生学教研室主任和省重点学科带头人，大连市分子毒理学重点实验室主任。获得6项国家自燃科学基金项目，4项日本文部科学省基金海外项目等，发表SCI论文100多篇。从2020年1月至今，为澳门新葡官网进入特聘专家。目前，主要从事环境化学物对神经和生殖系统的毒作用机制研究；干细胞及其外泌体移植对受损神经组织再生修复的机制研究。

社会兼职及荣誉：

担任国际牛磺酸学会学术理事

日本卫生学会委员

日本公众卫生学会东海地区委员

曾担任第二十一届国际牛磺酸学术大会主席

第72届日本卫生学会组委会秘书长

日本大气环境学会东海地区分会秘书长

2010年全国生化/工业与卫生毒理学学术大会主席

兼任国内外多个大学的客座教授

代表性研究成果：

代表性文章：

1. Shuangyue Li, Huai Guan, Yan Zhang, Sheng Li, Kaixin Li, Shuhai Hu, Enjun Zuo, Cong Zhang, Xin Zhang, Guanyu Gong, Ruoyu Wang, Fengyuan Piao*. Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell diferentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity. Stem Cell Res Ther, 2021, 12: 436.

2. Piao F, Chen Y, Yu Li, Shi X, Liu X, Jiang L, Yang G, Gao B and Zhang C. 2,5-hexanedione-induced deregulation of axon-related microRNA expression in rat nerve tissues. Toxicology Letters. 2020, 320: 95-102.

3. Li K, Shi X, Luo M, Inam-U-Llah, Wu P, Zhang M, Zhang C, Li Q, Wang Y and Piao F*. Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Exp Cell Res, 2019, 383(2): 111557.

4. Yang Z, Li T, Li S, Wei M, Qi H, Shen B, Chang RC, Le W, Piao F*. Altered expression levels of microRNA-132 and Nurr1 in peripheral blood of Parkinson's disease: a potential disease biomarker. ACS Chem Neurosci. 2019, 10(5): 2243-2249.

5. Hao J, Li S, Shi X, Qian Z, Sun Y, Wang D, Zhou X, Qu H, Hu S, Zuo E, Zhang C, Hou L, Wang Q, Piao F*. Bone marrow mesenchymal stem cells protect against n-hexane-induced neuropathy through beclin 1-independent inhibition of autophagy. Sci Rep. 2018, 8(1): 4516

6. Sun J, Shi X, Li S, Piao F*. 2,5-hexanedione induces bone marrow mesenchymal stem cell apoptosis via inhibition of Akt/Bad signal pathway. J Cell Biochem, 2018, 119(4): 3732-3743

7. Guan H, Li S, Guo Y, Liu X, Yang Y, Guo J, Li S, Zhang C, Shang L, Piao F*. Subchronic Exposure to Arsenic Represses the TH/TRβ1-CaMK IV Signaling Pathway in Mouse Cerebellum, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17(2). pii: E157. doi: 10.3390/ijms17020157.

8. Pan X, Jiang L, Zhong L, Geng C, Jia L, Liu S, Guan H, Yang G, Yao X, Piao F*, Sun X. Arsenic induces apoptosis by the lysosomal-mitochondrial pathway in INS-1 cells，ENVIRONMENTAL TOXICOLOGY，2016, 31 ( 2 ): 133-141.

9. Wang Q, Sun G, Gao C, Feng L, Zhang Y, Hao J, Zuo E, Zhang C, Li S, Piao F*. Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway. Scientific Reports, 2016, 6: 34715.

10. Cong Zhang, Sheng Li, Yahui Sun, Wei Dong, Fengyuan Piao*, Yongjun Piao, Shuang liu, Huai Guan, Shengbo Yu. Arsenic downregulates gene expression at the postsynaptic density in mouse cerebellum, including genes responsible for long-term potentiation and depression. Toxicol Lett, 2014, 228(3): 260–269

11. Jian Zhang, Xiaohui Liu, Lian Zhao, Shuhai Hu, Sheng Li, Fengyuan Piao*. Subchronic exposure to arsenic disturbed the biogenic amine neurotransmitter level and the mRNA expression of the synthetase in mice brains. Neuroscience, 2013, 41: 2-8

12. Yachen Li, Man Wang, Fengyuan Piao*, Xianghu Wang. Subchronic exposure to arsenic inhibits spermatogenesis and downregulates the expression of Ddx3y in testis and epididymis of mice. Toxicological Sciences, 2012, 128(2)：482–489

13. Shuang Liu, Fengyuan Piao*, Xiance Sun, Lulu Bai, Yan Peng, Yuanxia Zhong, Ning Ma, Wenchang Sun. Arsenic-induced inhibition of hippocampal neurogenesis and its reversibility. NeuroToxicology, 2012, 33(5): 1033-1039

14. Huai Guan, Fengyuan Piao*. Maternal and fetal exposure to uranium in Dalian, China. Acta Obstetricia et Gynecologica Scandinavica, 2011, 90(8): 924-925

15. Huai GUAN, Fengyuan PIAO*, Xiaowei LI, Qiujuan LI, Lei XU and Kazuhito YOKOYAMA. Maternal and Fetal Exposure to Four Carcinogenic metals Associated With Environmental Influencing Factors. Biomedical and Environmental Sciences, 2010, 23: 341-349

16. Yan Hong, Fengyuan Piao* Yufeng Zhao, Sheng Li, Yanyan Wang, Peng Liu. Subchronic exposure to arsenic decreased Sdha expression in the brain of Mice. Neurotoxicology, 2009, 30 (4): 538-543

17. Yanyan Wang, Sheng Li, Fengyuan Piao* YanHong, PengLiu, YufengZhao. Subchronic exposure to arsenic downregulated the expression of Camk4 as an important gene related to the late phase of cerebellar LTD of mice. Neurotoxicology and Teratology, 2009, 31(5): 318-322

18. Fengyuan Piao*, Guang Yang, Qiujuan Li, Jianxin Ye. Taurine and vitamin C prevent RNA damage in brain tissue of mice subchronically exposed to arsenic. Neural Regeneration Research, 2009, 4(11): 838-842

19. Fengyuan Piao*, Kazuhito Yokoyama, Ning Ma, Toru Yamauchi. Subacute toxic effects of zinc on various tissues and organs of rats. Toxicology Letters, 2003, 145: 28-35

20. Fengyuan Piao*, Toru Yamauchi, Ning Ma. The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds. Toxicology Letters, 2003, 143: 65-71

英文专著：

1. Jianmin Hu, Fengyuan Piao（共同主编）, Stephen W. Schaffer, Abdeslem El

Idrissi, Jang-Yen Wu. Taurine 11. Springer Nature Singapore Pte Ltd. 2019, Page: 1-1081.

2. Fengyuan Piao, Shuangyue Li, and Huai Guan. Developmental Arsenic

Exposure Impacts Fetal Programming of the Nervous System in the 1st edition of Handbook of Arsenic Toxicology Edited by S. J. S. Flora. Elsevier. 2015, Page: 1-701.

3. Fengyuan Piao, Shuangyue Li, and Huai Guan. Developmental Arsenic

Exposure Impacts Fetal Programming of the Nervous System in the second edition of Handbook of Arsenic Toxicology Edited by S. J. S. Flora. Elsevier. 2022, Page:

4. Fengyuan Piao. Taurine 11. in Chapter 7 of Toxicology in PART Ⅲ

ENVIRONMENTAL HEALTH of PUBLIC HEALTH & PREVENTIVE MEDICINE Edited by Niu Qiao. McGraw-Hill Education and China Science Publishing & Media Ltd. 2020, Page: 162-341.

5. Fengyuan Piao, Bihu Gao, Xiaolin Yuan1, Shuangyue Li, Cong Zhang, Xiuyan Sun, Qing Zhang. Taurine ameliorates Oxidative Stress in spinal cords of diabetic rats via Keap-Nrf2 in Taurine 12 Edited by Stephen Schaffer. Springer. 2022, Page:

获奖情况：

1. 大连市科学技术二等奖，朴丰源，2012J-2-17-01, 2013年11月，孕期有毒微量元素水平对新生儿发育影响分析及产后保健指导

招聘博士后的专业方向要求：

最好是研究神经系统和生殖系统的疾病机制或肿瘤诱发机制以及干细胞再生修复机制方向的。不过，根据博士毕业课题内容，如果有切入点，其他专业方向毕业的也可以考虑。对应聘博士毕业生，要求具有较熟练的多种分子生物学检测技术和构建动物模型和细胞培养技术，或者具有较强的流行病学调查和数据统计分析能力。

工作照照片：